How does Mesembrine work:

The brain is made up of countless neurons, which transmit signals to each other only by jumping the gap (synapse) to neighboring neurons. The signal cannot however jump the synapse without assistance.

The message can only travel when the neuron releases a neurotransmitter to fill this gap and allow the signal to transient via it.

The receiving neuron has many points on its surface that which act as potential locks, each of which is known as a receptor and is effected by a particular type of neurotransmitter. When sufficient amounts of the neurotransmitter are received by the relevant receptor, a nerve impulse is started and the message continues to its ultimate destination. To permit recovery of the neuron to receive new messages, the brain takes away the neurotransmitter from the neuron receptors and permitting it to be sent back to the originating nerves, a process known as re-uptake.

In individuals suffering from depression, the neurotransmitter serotonin (also known as 5-hydroxytryptamine) is lacking. Mesembrine slows down the re-uptake process, making it more probable there will be more serotonin in the relevant receptors, greatly increasing the possibility that there will be sufficient levels to set up the signal transfer in all neighboring neurons.

Mesembrine allows the brain to function with reduced levels of serotonin, allowing time for natural levels to build up, whereupon the mesembrine dosage can be reduced or eliminated.
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